Rabbit Anti-Sodium hydrogen exchanger 1/FITC Conjugated antibody

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amiloride-sensitive; APNH; APNH1; FLJ42224; Na Li countertransporter; Na(+)/H(+) antiporter; Na(+)/H(+) exchanger 1; Na+ H+ antiporter amiloride-sensitive; Na+ H+ antiporter; Na+ H+ exchanger 1; NHE-1; NHE1; OTTHUMP00000004468; SL9A1_HUMAN;

Cat:

SL0505R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human NHE1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

91kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Subunit:
Oligomer. Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic SLCterminus domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Kidney and intestine.

Post-translational modifications:
O-glycosylated.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1.

Similarity:
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Database links:

Entrez Gene: 6548 Human

Entrez Gene: 20544 Mouse

Entrez Gene: 24782 Rat

Omim: 107310 Human

SwissProt: P19634 Human

SwissProt: Q61165 Mouse

SwissProt: P26431 Rat

Unigene: 469116 Human

Unigene: 4312 Mouse

Unigene: 5025 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

通道蛋白（Channel Protein）
钠-氢交换蛋白（NHE： Na+/H+ Exchanger）是维持细胞内环境的主要细胞膜蛋白质之一，它的一个主要功能是调节细胞内pH值，使之保持在生理范围之内。细胞内pH值的变化，直接或间接的影响细胞的生长分裂、增殖和分化，也影响细胞的死亡。
钠-氢交换蛋白质的活性还影响细胞的移动和肿瘤细胞的转移。
目前主要方向是：研究消化道肿瘤细胞转移。

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