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Rabbit Anti-N-cadherin/FITC Conjugated antibody
background:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Subcellular Location:
Cell membrane.
Similarity:
Contains 5 cadherin domains.
Database links:
Entrez Gene: 1000 Human
Entrez Gene: 281062 Cow
Entrez Gene: 12558 Mouse
Entrez Gene: 83501 Rat
Omim: 114020 Human
SwissProt: P19022 Human
SwissProt: P15116 Mouse
SwissProt: Q9Z1Y3 Rat
Unigene: 464829 Human
Unigene: 606106 Human
Unigene: 257437 Mouse
Unigene: 2640 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞粘附蛋白(Call Adhesion Protein)
N-钙粘附分子属于依赖钙离子的细胞间糖蛋白粘附分子的一部分,主要是参与细胞间同源性粘附,调控和介导细胞间相互反应。
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