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Rabbit Anti-CCL3/FITC Conjugated antibody
background:
Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the SLCC chemokine receptor-1 (SLCC CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.
Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HISLVsuppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HISLV1, HISLV2, and simian immunodeficiency virus (SIV).
Subunit:
Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
Subcellular Location:
Secreted.
Post-translational modifications:
N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
Database links:
Entrez Gene: 6348 Human
Entrez Gene: 20302 Mouse
Entrez Gene: 25542 Rat
Omim: 182283 Human
SwissProt: P10147 Human
SwissProt: P10855 Mouse
SwissProt: P50229 Rat
Unigene: 514107 Human
Unigene: 1282 Mouse
Unigene: 10139 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
巨噬细胞炎症蛋白1α(MIP-1α)是CC趋化因子中的一种。主要用于炎症、肿瘤方面的研究。
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