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Rabbit Anti-Melan A/FITC Conjugated antibody
background:
Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.
Function:
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Subunit:
Interacts with PMEL. Interacts with GPR143.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Tissue Specificity:
Expression is restricted to melanoma and melanocyte cell lines and retina.
Post-translational modifications:
Acylated.
Database links:
Entrez Gene: 2315 Human
Omim: 605513 Human
SwissProt: Q16655 Human
Unigene: 154069 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号中间体(Signaling Intermediates)
MelanA/MART-1是分化肿瘤抗原类别中具有代表性的成员,它表达于正常的黑素细胞和大多数原发及转移的黑色素瘤中,故称:黑色素瘤相关抗原。
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