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Rabbit Anti-Megsin/FITC Conjugated antibody
background:
Serpin B7 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in a search for agents responsible for thrombopoiesis, and maturation of megakaryocytes. SerpinB7 was identified as a protein that increased acetylcholine esterase stimulation from bone barrow progenitor cells, and injection of SerpinB7 in mice induced a 40% increase in platelets compared to controls. Shortly thereafter, in a search for kidney specific genes, SerpinB7 was described as a protein specific to mesangial cells, and was named megsin to indicate the tissue specificity of the protein.
Function:
Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in mesangial cells.
Similarity:
Belongs to the serpin family. Ov-serpin subfamily.
Database links:
Entrez Gene: 8710 Human
Omim: 603357 Human
SwissProt: O75635 Human
Unigene: 138202 Human
Unigene: 742388 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
megsin是新近发现的蛋白质,属于丝氨酸蛋白酶抑制剂（Serpin）超家族，特异表达于肾小球系膜细胞,其表达异常在肾脏疾病进展中具有重要作用,megsin蛋白适量的表达，对维持人体正常的生理病理过程如凝血、纤维溶解、间质代谢、发育、血压、肿瘤和炎症等是很重要的。在系膜细胞增生和系膜基质增多明显的IgA肾病肾小球中，megsin的表达显著上调。
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