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Home > Product > Antibody > Rabbit Anti-MCP1/FITC Conjugated antibody
MCP-1; monocyte chemotactic protein 1; CCL 2; CCL2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF2; HC11; HSMCR30; JE; MCAF; MCP 1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating fac
Cat:
SL1101R-FITC
Species Reactivity：
(predicted: Mouse,Rat,)
Immunogen：
KLH conjugated synthetic peptide derived from rat MCP-1
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
11kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Processing at the N-terminus can regulate receptor and targetcell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility Belongs to the intercrine beta (chemokine CC) family. The MCP-1( the monocyte chemotactic protein1) has many pits that regulates the function toward sex to turn to record the factor, it can induce to have relation with inflammation with the immunity various genes turn to record.The immunity MCP-1 set turns the male signal to mainly locate the afterbirth syrup inside.

Function:
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Subunit:
Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.

Subcellular Location:
Secreted.

Post-translational modifications:
Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

Database links:

Entrez Gene: 6347 Human

Entrez Gene: 20296 Mouse

Entrez Gene: 24770 Rat

Omim: 158105 Human

SwissProt: P13500 Human

SwissProt: P10148 Mouse

SwissProt: P14844 Rat

Unigene: 303649 Human

Unigene: 29064 Mouse

Unigene: 4772 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）

巨噬细胞趋化蛋白1(MCP1)具有多向性调节作用的核转录因子，它可诱导与免疫和炎症有关的多种基因转录.MCP-1免疫组化阳性信号主要位于胞浆内。
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