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Rabbit Anti-MAdCAM-1/FITC Conjugated antibody
background:
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Function:
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity).
Subunit:
Homodimer (Probable).
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Detected in Peyer patches and mesenteric lymph nodes but not in spleen.
Similarity:
Contains 3 Ig-like (immunoglobulin-like) domains.
Database links:
Entrez Gene: 17123 Mouse
SwissProt: Q61826 Mouse
Unigene: 391556 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MAdCAM-1(粘膜血管定居因子或黏膜地址素细胞黏附分子)、CD44等均参与癌症和肿瘤细胞与血管内皮的相互作用,与癌症和肿瘤细胞一起穿过血管内皮而进入血管内,参与血行播散转移。
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