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Rabbit Anti-IQGAP1/FITC Conjugated antibody
background:
IQGAP1 is a widely expressed protein than interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology. It binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Function:
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Subunit:
Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Post-translational modifications:
Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
Similarity:
Contains 1 CH (calponin-homology) domain.
Contains 4 IQ domains.
Contains 1 Ras-GAP domain.
Contains 1 WW domain.
Database links:
Entrez Gene: 8826 Human
Entrez Gene: 29875 Mouse
Entrez Gene: 361598 Rat
Omim: 603379 Human
SwissProt: P46940 Human
SwissProt: Q9JKF1 Mouse
Unigene: 430551 Human
Unigene: 207619 Mouse
Unigene: 106939 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
支架蛋白IQGAP1与许多重要的细胞活动紧密相关，如黏附和迁移。研究发现在损伤修复、组织发展、肿瘤转移等过程中，IQGAP1的表达和功能有明显改变。同时作为Rh.GTPase信号的主要效应因子，IQGAP1能传递细胞外信号至黏附素复合体、细胞骨架以及细胞核。通过上述信号通路，IQ-GAP1协助细胞完成一系列重要生理病理活动。
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