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Rabbit Anti-Integrin alpha 4/FITC Conjugated antibody
background:
Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.
Function:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:
Heterodimer of an alpha and a beta subunit.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Post-translational modifications:
Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Database links:
Entrez Gene: 3676 Human
Entrez Gene: 11281 Mouse
Omim: 192975 Human
SwissProt: P13612 Human
SwissProt: Q00651 Mouse
Unigene: 88955 Human
Unigene: 31903 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素-α-4型 Integrin α4 (CD49d)整合素-α是介导细胞与细胞外基质粘附作用的主要因子。
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