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Rabbit Anti-IL-13/FITC Conjugated antibody
background:
Human IL13 was originally identified by differential screening of an anti CD28 activated human peripheral blood mononuclear cell cDNA library as an induction specific novel cytokine. It was also isolated from cDNA libraries of human T cell clones using the murine IL13 (P600) cDNA as a probe. Human IL13, a pleiotropic cytokine, is produced by activated Th0, Th1 like, Th2 like, and CD8 T cells. The gene for human IL13 maps to chromosome 5 and is closely linked to the genes for IL3, IL4, IL5, and GMCSF.
IL13 inhibits proinflammatory cytokine production and stimulates antibody production. It induces proliferation in the human pre myeloid cell line TF1. IL13 has multiple effects on the differentiation and functions of monocytes and macrophages. It suppresses cytotoxic functions and induces changes in the morphology of human monocytes and in the phenotype of human monocytes and B cells by upregulating MHC class II expression. IL13 will also decrease the production of nitric oxide by activated murine macrophages, leading to impaired parasiticidal activity.
Human and mouse interleukin 13 share approximately 58% amino acid sequence identity. Although human and mouse IL13 are equally active on human cells, human IL13 is much less active than mouse IL13 on mouse cells. Human IL13 and human IL4 also share approximately 30% sequence homology and have similar biological functions.
Function:
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
Subcellular Location:
Secreted.
DISEASE:
Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
Similarity:
Belongs to the IL-4/IL-13 family.
Database links:
Entrez Gene: 3596 Human
Entrez Gene: 16163 Mouse
Entrez Gene: 116553 Rat
Omim: 147683 Human
SwissProt: P35225 Human
SwissProt: P20109 Mouse
SwissProt: P42203 Rat
Unigene: 845 Human
Unigene: 1284 Mouse
Unigene: 9921 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子和激素（ Growth Factor and Hormones）
IL-13是由Ｔ细胞、嗜碱粒细胞、浆细胞及树突状细胞产生的细胞因子。
IL-13诱导、维持一定IgE水平，增强巨噬细胞及树突状细胞活性，活化嗜酸粒细胞并防止其凋亡，广泛参与过敏性及炎性疾病过程。
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