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Rabbit Anti-ICAD/FITC Conjugated antibody
background:
Caspase-activated deoxyribonuclease(CAD) also designated DNA fragmentation factor 45 kDa subunit (DFF-45)and Caspase-activated DNase. CAD is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. ICAD (DNA fragmentation factor alpha subunit) (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) is inhibitor of the caspase-activated DNase (DFF44).
Function:
Inhibitor of the caspase-activated DNase (DFF40).
Subunit:
Heterodimer of DFFA and DFFB.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
Similarity:
Contains 1 CIDE-N domain.
Database links:
Entrez Gene: 1676 Human
Omim: 601882 Human
SwissProt: O00273 Human
Unigene: 484782 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ICAD 是在细胞凋亡期诱导DNA分裂和染色体固缩的一种核酶,降解裸露的DNA 并诱导形态学变化。
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