background:
HBV surface proteins [Hepatitis B virus]. Major surface antigen from hepadnavirus; pfam00695.
Function:
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
Subunit:
Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion.
Subcellular Location:
Virion membrane.
Post-translational modifications:
Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region.
Myristoylated.
Similarity:
Belongs to the orthohepadnavirus major surface antigen family.
Database links:
UniProtKB/Swiss-Prot: P03140.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乙型肝肝炎病毒颗粒直径42nm，由包膜与核衣壳组成，包膜含有碳水化合物、蛋白质和脂类。其中蛋白质为主要抗原成分，包括S抗原：pre-s1区和pre-s2区，这些抗原成分在病毒侵入细胞过程中有着至关重要的作用，为深入研究乙型肝肝炎病毒发病机理及变异有着至关重要的作用。
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