background:
BRI3BP is a 251 amino acid multi-pass membrane protein. Though widely expressed, BRI3BP is found at highest levels in brain, kidney and liver where it localizes to the endoplasmic reticulum (ER) and is involved in ER structural dynamics and mitochondrial viability. Possessing pro-apoptotic properties and the ability to potentiate drug-induced apoptosis, BRI3BP overexpression has been shown to enhance caspase-3 and mitochondrial cytochrome c release in etoposide-treated human embryonic kidney 293T cells. The gene encoding BRI3BP maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.
Function:
Involved in tumorigenesis and may function by stabilizing p53/TP53.
Subunit:
Interacts with LETMD1.
Subcellular Location:
Mitochondrion outer membrane; Multi-pass membrane protein (Probable).
Tissue Specificity:
Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.
Database links:
Entrez Gene: 140707 Human
Entrez Gene: 71369 Mouse
SwissProt: Q8WY22 Human
SwissProt: Q8BXV2 Mouse
Unigene: 596464 Human
Unigene: 290720 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人宫颈癌基因（HCCR）是新近确定的一种癌基因，人宫颈癌蛋白： HCCR-1和HCCR-2两种蛋白。HCCR1不仅在宫颈癌组织中表达，而且在人其他肿瘤如白血病、淋巴瘤、乳腺癌、肾B 癌、胃癌、结肠癌、肝癌和子宫癌中均有过度表达，可作为肝癌及乳腺癌诊断的标志物。
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