Rabbit Anti-HAI-1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-HAI-1/FITC Conjugated antibody

Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1; SPIT1_HUMAN.

Cat:

SL0540R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human HAI-1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

55kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.

Function:
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

Subunit:
Interacts with HGFAC.

Subcellular Location:
Secreted.

Similarity:
Contains 2 BPTI/Kunitz inhibitor domains.
Contains 1 LDL-receptor class A domain.
Contains 1 MANSC domain.

Database links:

Entrez Gene: 6692 Human

Omim: 605123 Human

SwissProt: O43278 Human

Unigene: 233950 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HAI-1 是一种含两个 Kunitz 域的跨膜蛋白，可抑制由细胞膜分泌的并且以游离形式存在的 HGFA 。 HAI-1 也可以作用于其它丝氨酸蛋白酶.
HAI-1 主要在胎盘、肾、胰腺、前列腺和小肠，也有报道称 HAI-1 会在肝癌中表达。

Product Feedback Wall