Rabbit Anti-TNFRSF18/FITC Conjugated antibody

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Activation inducible TNFR family receptor; Activation-inducible TNFR family receptor; CD357; AITR; GITR; GITR D; GITR-D; GITRD; Glucocorticoid induced TNFR related protein; glucocorticoid-induced tnf receptor ligand; Glucocorticoid induced TNFR related pr

Cat:

SL1173R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human TNFRSF18

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

24kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.

Function:
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Subunit:
Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its SLCterminus to SIVA1/SIVA.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Tissue Specificity:
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Similarity:
Contains 3 TNFR-Cys repeats.

Database links:

Entrez Gene: 8784 Human

Entrez Gene: 21936 Mouse

Omim: 603905 Human

SwissProt: Q9Y5U5 Human

SwissProt: O35714 Mouse

Unigene: 21536 Human

Unigene: 336 Mouse

Unigene: 482508 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GITR属于肿瘤坏死因子受体超家族（TNFRSF），GITR参与免疫调节信号，在T细胞的活化、凋亡,尤其是阻断调节性T细胞（T regulatory cell）的抑制功能等活动中发挥主要作用。

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