Rabbit Anti-Gax/FITC Conjugated antibody

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growth arrest-specific homeobox; Homeobox protein MOX-2; Mesenchyme homeobox 2; mesenchyme homeobox 2-like; Growth arrest-specific homeobox; GAX; growth arrest homeobox transcription factor GAX; mesenchyme homeobox 2; MEOX2_HUMAN.

Cat:

SL1250R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Gax

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

33kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimers disease.

Function:
Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

Subunit:
Interacts with RNF10.

Subcellular Location:
Nucleus. Nucleus speckle.

Similarity:
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 4223 Human

Entrez Gene: 17286 Mouse

Entrez Gene: 29279 Rat

Omim: 600535 Human

SwissProt: P50222 Human

SwissProt: P32443 Mouse

SwissProt: P39020 Rat

Unigene: 170355 Human

Unigene: 341398 Mouse

Unigene: 34890 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gax主要在血管平滑肌细胞和内皮细胞中表达的同源异形盒基因,但Gax基因过表达可以抑制血管平滑肌细胞和内皮细胞的增殖，Gax也是脊椎动物肢体发育的重要调节因子，目前除用于心血管方面的研究，也用于肿瘤血管方面的探索。

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