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Rabbit Anti-Myeloperoxidase/FITC Conjugated antibody
background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].
Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Subunit:
Tetramer of two light chains and two heavy chains.
Subcellular Location:
Lysosome.
DISEASE:
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:25920]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Similarity:
Belongs to the peroxidase family. XPO subfamily.
Database links:
Entrez Gene: 4353 Human
Entrez Gene: 17523 Mouse
Entrez Gene: 303413 Rat
Omim: 606989 Human
SwissProt: P05164 Human
SwissProt: P11247 Mouse
Unigene: 458272 Human
Unigene: 4668 Mouse
Unigene: 47782 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
髓过氧化物酶MPO,作为一种白细胞酶,具有介导炎性反应、调节免疫应答等多种功能,并可参与疾病的发生发展过程。同时,髓过氧化物酶基因存在基因多态性,也影响机体对疾病的易感性. 在正常淋巴组织中和各种髓样细胞增生症中,MPO均有较强表达,如:淋巴样细胞、原核细胞、肥大细胞、浆细胞以及各种上皮源性肿瘤和肉瘤等。
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