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Rabbit Anti-GFRA4/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Function:
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in SLCcell development and, in the postnatal development of the adrenal medulla.
Subcellular Location:
Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform GFRalpha4c: Secreted.
Tissue Specificity:
Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
Similarity:
Belongs to the GDNFR family.
Database links:
Entrez Gene: 12896 Human
SwissProt: Q9GZZ7 Human
Unigene: 302025 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Persephin receptor 是一个新的神经营养因子,属于GDNFR家族,调节GDNF诱导的自动磷酸化和RET受体的活性。他在维持神经系统正常生存中起重要作用。主要表达在正常和恶性甲状腺髓细胞。分子量约为30kDa。
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