background:
Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, Fos B, (fos-related antigen) Fra 1, and Fra 2. Also named as DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; Oncogene FOS B; Protein fosB.
Function:
FosB interacts with Jun proteins enhancing their DNA binding activity.
Subunit:
Heterodimer.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
Database links:
Entrez Gene: 2354 Human
Entrez Gene: 10072176 Rat
Omim: 164772 Human
SwissProt: P53539 Human
Unigene: 590958 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录调节因子(Transcriptin Regulators)
FOS B属于转录因子AP-1家族;FosB是一种转录因子,表达后能在脑内维持数周甚至几个月。长期药物滥用能引起伏核内FosB表达稳定地增加,表明FosB的表达可能是药物成瘾的分子转换机制,是当今药物成瘾研究中最受重视的转录因子。
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