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Rabbit Anti-KGF/FITC Conjugated antibody
background:
KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Subunit:
Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted.
Tissue Specificity:
Epithelial cell.
Similarity:
Belongs to the heparin-binding growth factors family.
Database links:
Entrez Gene: 2252 Human
Entrez Gene: 14178 Mouse
Entrez Gene: 29348 Rat
Omim: 14836 Human
SwissProt: P21781 Human
SwissProt: P36363 Mouse
SwissProt: Q02195 Rat
Unigene: 567268 Human
Unigene: 330557 Mouse
Unigene: 98842 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KGF/FGF7 (Fibroblast growth factor 7) 又称:HBGF-7 纤维母细胞生长因子7,是FGF家族的主要成员之一。
FGF家族参与细胞生长、组织修复、胚胎生长发育、组织器官的形成、肿瘤的生长和侵润等诸多生理病理功能。
成纤维细胞生长因子7的促增生作用主要来源于角化上皮细胞而不是间质细胞和内皮细胞,因此人们又称之为:角化上皮细胞生长因子(KGF)。
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