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Rabbit Anti-Egr1/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq].
Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGSLC3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the EGR C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
Database links:
Entrez Gene: 1958 Human
Entrez Gene: 13653 Mouse
Omim: 128990 Human
SwissProt: P18146 Human
SwissProt: P08046 Mouse
Unigene: 326035 Human
Unigene: 708393 Human
Unigene: 181959 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Egr-1为即刻早期基因家族中的一个成员,是一种含3个锌指结构的转录因子。有研究表明EGR-1在细胞生长分化中发挥重要作用,如在细胞周期G1-S期的转换过程中Egr-1被诱导表达。
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