background:
EBNA3A is a latent viral nuclear protein expressed in Epstein Barr Virus (EBV) transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA3A functions as a transcriptional regulator though the target genes are currently unknown.
Function:
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
Subunit:
Interacts with human UCKL1. Interacts with host CTPB1; this interaction seems important for EBNA3-mediated transcriptional repression. Interacts with host RBPJ.
Subcellular Location:
Host nucleus matrix. Note=Associated with the nuclear matrix.
Similarity:
Belongs to the herpesviridae EBNA-3 family.
Database links:
Entrez Gene: 3783762 EBVG
SwissProt: Q3KST2 EBVG
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
EB病毒核抗原-3（nuclear antigen EBNA-3）是EB病毒编码核蛋白，位于细胞核的新的酶聚合体，主要作为转录调节因子，指导蛋白与蛋白之间相互作用，为核糖核苷酸补救途径的一部分.
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