background:
DVL1 may play a role in the signal transduction pathway mediated by multiple Wnt genes. [Subunit] Interacts with BRD7 and INVS. Interacts through its PDZ domain with the SLCterminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN (By similarity). Interacts with CXXC4. [Subcellular Location] Cytoplasm (Potential). Belongs to the DSH family.
Function:
Participates in Wnt signaling by binding to the cytoplasmic SLCterminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Subunit:
Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the SLCterminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity).
Subcellular Location:
Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members.
Post-translational modifications:
Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
Similarity:
Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
Database links:
Entrez Gene: 1855 Human
Entrez Gene: 13542 Mouse
Entrez Gene: 83721 Rat
Omim: 601365 Human
SwissProt: Q5IS48 Chimpanzee
SwissProt: O14128 Human
SwissProt: P51141 Mouse
SwissProt: Q9WVB9 Rat
Unigene: 741165 Human
Unigene: 3400 Mouse
Unigene: 144610 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
dishevelled-1蓬乱蛋白-1主要用于神经退行性改变-AD病方面的研究.
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