Rabbit Anti-CTGF/FITC Conjugated antibody

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CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; CTGF; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tis

Cat:

SL0743R-FITC

Species Reactivity：

Human,Mouse,Rat,(predicted: Chicken,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human CTGF (202-241aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].

Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Subunit:
Monomer.

Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted.

Tissue Specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Similarity:
Belongs to the CCN family.
Contains 1 CTCK (SLCterminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Database links:

Entrez Gene: 1490 Human

Entrez Gene: 12832 Rat

Omim: 121009 Human

SwissProt: P29279 Human

SwissProt: P29268 Mouse

SwissProt: Q9R1E9 Rat

Unigene: 410037 Human

Unigene: 390287 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）
结缔组织生长因子（CTGF）是调节细胞增生、分化和细胞外基质形成的重要效应分子,可调节机体有关组织、细胞生长并与纤维化发生密切相关的一种因子，因而在肌体的各类创伤修复过程中具有重要的生理学意义。

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