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Rabbit Anti-CRP/FITC Conjugated antibody
background:
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and SLCreactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.
Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Subunit:
Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
Subcellular Location:
Secreted.
Tissue Specificity:
Found in plasma.
Similarity:
Belongs to the pentaxin family.
Contains 1 pentaxin domain.
Database links:
Entrez Gene: 1401 Human
Omim: 123260 Human
SwissProt: P02741 Human
Unigene: 76452 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C反应蛋白 CRP（SLCreactive protin）是与C性肺炎球菌的多糖起反应的一种蛋白，在某些细菌的感染过程中出现在血浆中。
CRP是在一些病理性情况下出现于病人血清中的一种糖蛋白，特别是在伴有肯炎症和组织坏死疾病的急性期。血清中出现的这种异常蛋白能和肺炎SLC多糖体发生沉淀反应，当疾病好转或缓解时，CRP减低或消失。
临床意义:
(1)各种急性化脓性炎症、菌血症、组织坏死(心肌梗塞、手术、严重创伤、烧伤等)、恶性肿瘤、结缔组织病、肾移殖后急性排异反应、急性风湿热、风湿性关节炎、类风湿性关节炎、心肌炎急性期、肺炎、肺结核、系统性红斑狼疮、急性肝炎和阑尾炎等，血清中CRP含量可增高，它的出现比其它急性期的反应物质早，所以对疾病的早期诊断很有帮助。
CRP可以鉴别细菌炎症或者是病毒性炎症。细菌性炎症CRP可以明显增高，而病毒性炎症CRP的血清含量一般都在正常范围。
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