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Home > Product > Antibody > Rabbit Anti-Collagen V/FITC Conjugated antibody
Collagen Type V; AB collagen; Alpha 1 type V collagen; Alpha 2 type V collagen; Col5A1; Col5A2; COL5A2 protein; Col5A3; Collagen alpha 1(V) chain; Collagen alpha 2 (V) chain precursor; Collagen alpha 2(V) chain; Collagen alpha 3(V) chain; Collagen fetal m
Cat:
SL0552R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human Collagen V
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
153kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].

Function:
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

Subunit:
Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Post-translational modifications:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sulfated on 40% of tyrosines.

DISEASE:
Ehlers-Danlos syndrome 1 (EDS1) [MIM:130000]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.
Ehlers-Danlos syndrome 2 (EDS2) [MIM:130010]: Mild form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 laminin G-like domain.

Database links:

Entrez Gene: 1289 Human

Entrez Gene: 1290 Human

Entrez Gene: 50509 Human

Omim: 120190 Human

Omim: 120215 Human

Omim: 120216 Human

SwissProt: P05997 Human

SwissProt: P20908 Human

SwissProt: P25940 Human

SwissProt: Q15094 Human

SwissProt: Q53WR4 Human

SwissProt: Q5PR22 Human

SwissProt: Q5SY11 Human

SwissProt: Q86XF6 Human

Unigene: 210283 Human

Unigene: 235368 Human

Unigene: 445827 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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