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Rabbit Anti-CCR-1/CD191/FITC Conjugated antibody
background:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
Function:
Receptor for a SLCC type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Subunit:
Interacts with CREB3.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed in different hematopoietic cells.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 1230 Human
Entrez Gene: 12768 Mouse
Omim: 601159 Human
SwissProt: P32246 Human
SwissProt: P51675 Mouse
Unigene: 301921 Human
Unigene: 274927 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
趋化因子是当今细胞因子研究领域的热点之一,它参与多种免疫及炎症反应,在感染、肿瘤的生长与转移、组织修复及创伤愈合等病理生理过程中发挥重要作用.
SLCC型趋化因子受体1(CCR1)主要在嗜酸粒细胞,Th2淋巴细胞,肥大细胞,支气管上皮细胞上表达.CCR1在肿瘤的生长与转移方面起到一定的作用.
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