Home
>
Product
>
Antibody
>
Rabbit Anti-Caspase-6 subunit p18/FITC Conjugated antibody
background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
Similarity:
Belongs to the peptidase C14A family.
Database links:
Entrez Gene: 839 Human
Entrez Gene: 12368 Mouse
Entrez Gene: 83584 Rat
Omim: 601532 Human
SwissProt: P55212 Human
SwissProt: O08738 Mouse
SwissProt: O35397 Rat
Unigene: 654616 Human
Unigene: 281379 Mouse
Unigene: 88160 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Caspase-6 与Caspase-3有38%的同源性,属胱氨酸-天冬氨酸蛋白酶家族。在凋亡执行阶段起中心作用,可被Caspase-7、-8、-10剪切。它是唯一一个可以剪切核纤层蛋白的Caspase。
|
|