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Rabbit Anti-Calpain 1/FITC Conjugated antibody
background:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Subunit:
Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
Subcellular Location:
Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca(2+) binding.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Similarity:
Belongs to the peptidase C2 family.
Contains 1 calpain catalytic domain.
Contains 4 EF-hand domains.
Database links:
Entrez Gene: 12333 Mouse
Entrez Gene: 823 Human
Entrez Gene: 29153 Rat
Omim: 114220 Human
SwissProt: P07384 Human
SwissProt: O35350 Mouse
SwissProt: P97571 Rat
Unigene: 502842 Human
Unigene: 6221 Mouse
Unigene: 6037 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙蛋白酶(calpain)是一族钙离子依赖性的、水解半胱氨酸的蛋白酶,广泛存在于全身各脏器组织中。钙蛋白酶参与不同细胞过程,包括细胞骨架和细胞膜附着的构型重建、不同的信号转导途径和细胞凋亡等.
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