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Rabbit Anti-DFFB/FITC Conjugated antibody
background:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].
Function:
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subunit:
Heterodimer of DFFA and DFFB
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Contains 1 CIDE-N domain.
Database links:
Entrez Gene: 1677 Human
Entrez Gene: 13368 Mouse
Entrez Gene: 84359 Rat
Omim: 601883 Human
SwissProt: O76075 Human
SwissProt: O54788 Mouse
SwissProt: Q99N34 Rat
Unigene: 133089 Human
Unigene: 388918 Mouse
Unigene: 67077 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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