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Rabbit Anti-BACE1/FITC Conjugated antibody
background:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated SLCterminal fragment which is later released by gamma-secretase.
Subunit:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated SLCterminal fragment which is later released by gamma-secretase.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the peptidase A1 family.
Database links:
Entrez Gene: 23621 Human
Entrez Gene: 23821 Mouse
Entrez Gene: 29392 Rat
Omim: 604252 Human
SwissProt: P56817 Human
SwissProt: P56818 Mouse
SwissProt: P56819 Rat
Unigene: 504003 Human
Unigene: 4844 Mouse
Unigene: 207201 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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