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Rabbit Anti-GLUT2/FITC Conjugated antibody
background:
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008].
Function:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Liver, insulin-producing beta cell, small intestine and kidney.
Post-translational modifications:
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
DISEASE:
Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
Similarity:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Database links:
Entrez Gene: 6514 Human
Entrez Gene: 20526 Mouse
Entrez Gene: 25351 Rat
Omim: 138160 Human
SwissProt: P11168 Human
SwissProt: P14246 Mouse
SwissProt: P12336 Rat
Unigene: 167584 Human
Unigene: 18443 Mouse
Unigene: 89295 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
交换和转运（Trafficking and Transport）
葡萄糖载运蛋白2 GLUT-2是胰岛B细胞膜上的转运蛋白，在血糖浓度升高时，促进GLUT2对葡萄糖的转运功能，继而刺激胰岛素释放。GLUT2分子对葡萄糖亲合力极低，似乎仅在血浆葡萄糖水平相对较高时才作为转运体发挥载体功能,GLUT2在胰岛B细胞的葡萄糖转运中起着重要作用
GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意义
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