Rabbit Anti-EphB2/FITC Conjugated antibody

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Eph receptor B2; Developmentally regulated EPH related tyrosine kinase; DRT; ELK related protein tyrosine kinase; EPH tyrosine kinase 3; EphB2; Ephrin type B receptor 2; EPHT 3; ERK; ETECK; Nuk; Prkm 5; Receptor protein tyrosine kinase HEK 5, Sek 3; Tyro

Cat:

SL0247R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Chicken,Dog,)

Immunogen：

KLH conjugated synthetic peptide derived from human EphB2 R

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

114kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL).

Subunit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Tissue Specificity:
Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.

DISEASE:
Defects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:171367]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 2048 Human

Entrez Gene: 13844 Mouse

Omim: 600997 Human

SwissProt: P29323 Human

SwissProt: P54763 Mouse

Unigene: 523329 Human

Unigene: 250981 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生长因子和激素（ Growth Factor and Hormones）
EphB2受体(Ephrin type-B receptor 2)在细胞生长、分化和信号转导过程中具有重要作用。有报道：EphB2受体(ephrinB2受体) 在中枢神经组织，肿瘤组织有较强的表达。促进肿瘤细胞浸润和新生血管形成.

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