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Rabbit Anti-ADNP/FITC Conjugated antibody
background:
The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor.
Function:
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Subcellular Location:
Nucleus (Potential).
Tissue Specificity:
Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.
Similarity:
Contains 9 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 23394 Human
Omim: 62286 Human
SwissProt: Q9H2P0 Human
Unigene: 570355 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
是一个潜在的转录调节因子,参与正常细胞与肿瘤细胞的增殖调控。
广泛分布于大脑、小脑等组织,在肺、肾、小肠以及睾丸等组织也有微弱的表达。对体外培养的glia缺失神经元细胞有保护作用.
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