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Rabbit Anti-ADAMTS7/FITC Conjugated antibody
background:
Metalloprotease that may play a role in the degradation of COMP. Binds 1 zinc ion per subunit. pH dependence: Optimum pH is between 7.5 and 9.5. [Subcellular location] Secreted, extracellular space, extracellular matrix (By similarity). Note=Also found associated with the external cell surface[Tissue specificity] Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments. Up-regulated in articular cartilage and synovium from arthritis patients.
Function:
Metalloprotease that may play a role in the degradation of COMP.
Subunit:
Interacts with COMP.
Subcellular Location:
Secreted, extracellular space, extracellular matrix. Note=Also found associated with the external cell surface.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.
Post-translational modifications:
N-glycosylated.
O-glycosylated proteoglycan. Contains chondroitin sulfate (By similarity).
May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.
Similarity:
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 8 TSP type-1 domains.
Database links:
Entrez Gene: 11173 Human
Omim: 605009 Human
SwissProt: Q6P7J9 Human
SwissProt: Q9UKP4 Human
Unigene: 16441 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素样金属蛋白酶与凝血酶1型-7用于动脉粥样硬化导致早期血管基质修复作用的研究
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