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Rabbit Anti-ADAMTS1/FITC Conjugated antibody
background:
ADAMTS1 is a metalloproteinase of the ADAM (A Disintegrin And Metalloproteinase) family containing disintegrin-like domains. ADAMTS1, also known as METH1, was first described as a protein elevated in invasive mouse tumors. Initial findings indicated a role for ADAMTS1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. ADAMTS1 is necessary for normal growth, fertility, and organ morphology and function.
Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Subcellular Location:
Secreted > extracellular space > extracellular matrix.
Post-translational modifications:
The precursor is cleaved by a furin endopeptidase.
Similarity:
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 3 TSP type-1 domains.
Database links:
Entrez Gene: 9510 Human
Entrez Gene: 11504 Mouse
Entrez Gene: 79252 Rat
Omim: 605174 Human
SwissProt: Q9UHI8 Human
SwissProt: P97857 Mouse
SwissProt: Q9WUQ1 Rat
Unigene: 643357 Human
Unigene: 8230 Human
Unigene: 1421 Mouse
Unigene: 7897 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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