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Rabbit Anti-ACE2/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoSLVNL63. [provided by RefSeq, Jul 2008].
Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoSLVNL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Subunit:
Interacts with ITGB1. Interacts with SARS-CoV and HCoSLVNL63 spike glycoprotein.
Subcellular Location:
Processed angiotensin-converting enzyme 2: Secreted.
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
Post-translational modifications:
N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form.
Belongs to the peptidase M2 family.
Similarity:
Belongs to the peptidase M2 family.
Database links:
Entrez Gene: 59272 Human
Entrez Gene: 70008 Mouse
Entrez Gene: 302668 Rat
Omim: 300335 Human
SwissProt: Q9BYF1 Human
SwissProt: Q8R0I0 Mouse
SwissProt: Q5EGZ1 Rat
Unigene: 35698 Human
Unigene: 13451 Mouse
Unigene: 129779 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
合成与降解（Synthesis and Degradation）
ACE-2的分布范围比较局限，ACE2主要在心脏、肾脏、睾丸中表达显著，
近来人们发现ACE2也分布在胃肠道、脑和肺脏中。
有关学者在研究心脏和肾脏中发现，ACE2在心肌缺血、肾功能衰竭、动脉粥样硬化和糖尿病并发症中，ACE2对血管紧张素产生和降解过程中有一定的生理作用。
特别是对ACE2在具有生理活性的-活性肽产生过程中的作用更值得进一步研究。 ACE2的发现为心血管病和肾脏病研究开辟了新天地，并提供了新的治疗靶点，可能导致未来心血管疾病治疗策略的改变。
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