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Rabbit Anti-Alpha-1-Antichymotrypsin/FITC Conjugated antibody
background:
Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease.
Function:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Subunit:
Interacts with DNAJC1.
Subcellular Location:
Secreted.
Tissue Specificity:
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Similarity:
Belongs to the serpin family.
Database links:
Entrez Gene: 12 Human
Omim: 107280 Human
SwissProt: P01011 Human
Unigene: 534293 Human
Unigene: 710488 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AACT是由神经胶质细胞分泌并参与淀粉样纤维生成和沉积的一种色氨酸蛋白酶抑制剂,被认为是Aβ肽的假性底物，与Aβ肽具有很高的亲合性，可促进Aβ肽的纤维化以生成淀粉样沉积。
ApoE作为AD的另一种病理伴随性物质，也可识别并与Aβ肽相结合，促进Aβ肽沉积生成淀粉样老年斑块。由于AACT和
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