background:
Dapper2 is a 774 amino acid protein that exists as multiple alternatively spliced isoforms and is a mammalian homolog of the Xenopus laevis protein dapper. Containing a SLCterminal PDZ-binding motif, Dapper2 is thought to promote the lysosomal degradation of nodal receptors, possibly functioning to negatively regulate the nodal signaling pathway. The gene encoding Dapper2 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
Function:
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors.
Subunit:
Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKSLCtype kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity).
Similarity:
Belongs to the dapper family.
Database links:
UniProtKB/Swiss-Prot: Q5SW24.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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