background:
Neurensin-1 (NRSN1), also designated Vesicular membrane protein of 24 kDa (VMP) or Neuro-p24, is a 195 amino acid multi-pass membrane protein belonging to the VMP family that is involved in the transport of neural organelle transport and in the transduction of nerve signals or in nerve growth. Expressed solely in brain, Neurensin-1 is also thought to play a role in neurite extension. The gene encoding Neurensin-2 maps to human chromosome 6, which contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6.
Function:
May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension.
Subcellular Location:
Membrane. Localizes mainly to neurites.
Tissue Specificity:
Expressed in brain. Not detectable in other tissues tested.
Similarity:
Belongs to the VMP family.
Database links:
Entrez Gene: 140767 Human
Entrez Gene: 2272 Mouse
Entrez Gene: 291129 Rat
SwissProt: Q8IZ57 Human
SwissProt: P97799 Mouse
Unigene: 726270 Human
Unigene: 4766 Mouse
Unigene: 225156 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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