background:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Function:
SOX21 is a transcription factor whose presence is key for the generation of neurons from precursor cells. The decision of neural cells to remain as progenitors or commit to neuronal differentiation seems to depend on the intrinsic balance of Sox21 and Sox1-3 activity
Subcellular Location:
Nuclear
Similarity:
Contains 1 HMG box DNA-binding domain.
Database links:
Entrez Gene: 11166 Human
Entrez Gene: 223227 Mouse
Omim: 604974 Human
SwissProt: Q9Y651 Human
SwissProt: Q811W0 Mouse
Unigene: 187577 Human
Unigene: 70950 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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