Rabbit Anti-CACNA2/FITC Conjugated antibody

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Calcium channel L type DHPR alpha 2 subunit; CA2D1_HUMAN; CACN A2; CACNA2; CACNA2D1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydrop

Cat:

SL11981R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CACNA2/CACNA2D1 (571-610aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

16/106/122kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.

Subunit:
Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.

Post-translational modifications:
Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.

Similarity:
Belongs to the calcium channel subunit alpha-2/delta family.
Contains 1 cache domain.
Contains 1 VWFA domain.

Database links:

Entrez Gene: 781 Human

Entrez Gene: 12293 Mouse

Entrez Gene: 397377 Pig

Entrez Gene: 25399 Rat

Omim: 114204 Human

SwissProt: P54289 Human

SwissProt: Q17R45 Human

SwissProt: Q9UIU0 Human

SwissProt: O08532 Mouse

SwissProt: Q14SH8 Mouse

SwissProt: Q3TQD0 Mouse

SwissProt: Q8C6Y3 Mouse

SwissProt: P2766 Rabbit

SwissProt: P54290 Rat

Unigene: 282151 Human

Unigene: 159842 Mouse

Unigene: 11276 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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