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Rabbit Anti-HUNK/FITC Conjugated antibody
background:
The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-α and CAB39.
Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
SNF1 subfamily.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 30811 Human
Entrez Gene: 26559 Mouse
Omim: 606532 Human
SwissProt: P57058 Human
SwissProt: O88866 Mouse
Unigene: 109437 Human
Unigene: 125874 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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