Rabbit Anti-Neurotensin Receptor 1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Neurotensin Receptor 1/FITC Conjugated antibody

High affinity levocabastine insensitive neurotensin receptor; Neurotensin receptor type 1; NT R 1; NTR; NTR1; NTRH; NTRR; NTR-1; NTSR 1; NTR1_HUMAN.

Cat:

SL2402R-FITC

Species Reactivity：

Human,

Immunogen：

KLH conjugated synthetic peptide derived from human NTR1/Neurotensin Receptor 1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive Neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). Neurotensin has a wide distribution in regions of the brain and in peripheral tissues where Neuro-tensin receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a five-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1b and TNFa in an ERK1/2- and Akt kinase-dependent manner.

Function:
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. NTR1 has been reported in brain, pancreas, and small intestine. ESTs have been isolated from brain and colon libraries.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.

Database links:

Entrez Gene: 4923 Human

Entrez Gene: 18216 Mouse

Omim: 162651 Human

SwissProt: P30989 Human

SwissProt: O88319 Mouse

Unigene: 590869 Human

Unigene: 301712 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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