Rabbit Anti-CACNG3/FITC Conjugated antibody

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CACNG 3; Cacng2; Calcium channel voltage dependent gamma subunit 3; Neuronal voltage gated calcium channel gamma 3 subunit; Voltage dependent calcium channel gamma 3 subunit; Voltage gated calcium channel gamma subunit; CCG3_HUMAN.

Cat:

SL12059R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human CACNG3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CACNG3 belongs to the PMP-22/EMP/MP20 family, CACNG subfamily. It is thought to stabilize the calcium channel in an inactivated (closed) state. CACNG3 is a candidate gene for a familial infantile convulsive disorder with paroxysomal choreoathetosis.

Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

Subunit:
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Database links:

Entrez Gene: 538496 Cow

Entrez Gene: 10368 Human

Entrez Gene: 54376 Mouse

Entrez Gene: 140724 Rat

Omim: 601283 Human

SwissProt: Q0VD05 Cow

SwissProt: O60359 Human

SwissProt: Q9JJV5 Mouse

SwissProt: Q8VHX0 Rat

Unigene: 7235 Human

Unigene: 444212 Mouse

Unigene: 212756 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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