Rabbit Anti-TWF2/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-TWF2/FITC Conjugated antibody

A6 related protein; A6r; A6RP; hA6RP; MSTP011; Protein tyrosine kinase 9 like; PTK 9L; PTK9L; PTK9L; PTK9L protein tyrosine kinase 9 like; TWF 2; Twinfilin 1 like protein; Twinfilin 2; Twinfilin actin binding protein homolog 2; Twinfilin like protein; Twi

Cat:

SL12044R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human TWF2/PTK9L

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

39kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase SLCzeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]

Function:
TWF2 (Twinfilin 2) was identified by its interaction with the catalytic domain of protein kinase C zeta. It contains an actin binding site and an ATP binding site and is most closely related to twinfilin (PTK9), a conserved actin monomer binding protein. TWF2 is an actin binding protein involved in motile and morphological processes. It inhibits actin polymerization, likely by sequestering G actin. By capping the barbed ends of filaments, it also regulates motility. It seems to play an important role in clathrin mediated endocytosis and distribution of endocytic organelles.

Subunit:
Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A

Subcellular Location:
Cytoplasmic, cytoskeleton. Cytoplasmic, perinuclear region. Note: Perinuclear and G actin rich cortical actin structures sublocalization.

Tissue Specificity:
Ubiquitously expressed (at protein level).

Post-translational modifications:
In vitro, phosphorylated by PRKCZ, CK2 and SRC.

Similarity:
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
Contains 2 ADF-H domains.

Database links:

Entrez Gene: 11344 Human

Entrez Gene: 23999 Mouse

Omim: 607433 Human

SwissProt: Q6IBS0 Human

SwissProt: Q9Z0P5 Mouse

Unigene: 436439 Human

Unigene: 274346 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall