background:
Transient receptor potential (TRP) proteins are cation-sensitive channels that modulate a myriad of cellular functions, including temperature sensation and vasoregulation Transcribed from a gene adjacent to VR-1, the thermal-sensitive, capsaicin-insensitive TRPV3 is expressed at warm temperatures; expression increases in response to noxious temperatures. Human TRPV3 is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain. In addition, TRPV3 is co-expressed in dosal root ganglion neurons with VR-1. TRPV3 associates with VR-1 and may modulate VR-1 activity. The 729 amino acid TRPV5 (ECAC1) protein comprises six transmembrane domains, multiple potential phosphorylation sites, an N-linked glycosylation site and three ankyrin repeat regions. It is abundantly expressed in kidney, jejunum and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. TRPV5 controls the rate-limiting step of vitamin D3-regulated Ca2+ reabsorption in kidney and intestine; the 5’-flanking region of TRPV5 contains four putative vitamin D3-responsive elements.
Function:
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity.
Subunit:
May form a heteromeric channel with TRPV1. Interacts with TRPV1.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level).
DISEASE:
Defects in TRPV3 are the cause of Olmsted syndrome (OLMS) [MIM:614594]. A rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes.
Similarity:
Belongs to the transient receptor (TC 1.A.4) family.
TrpV subfamily. TRPV3 sub-subfamily.
Contains 3 ANK repeats.
Database links:
Entrez Gene: 162514 Human
Entrez Gene: 246788 Mouse
Entrez Gene: 497948 Rat
Omim: 607066 Human
SwissProt: Q8NET8 Human
SwissProt: Q8K424 Mouse
Unigene: 446255 Human
Unigene: 347652 Mouse
Unigene: 75196 Mouse
Unigene: 163151 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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