background:
SLC35C2 (solute carrier family 35, member C2), also known as C20orf5, OVCOV1 or CGI-15, is a 365 amino acid multi-pass membrane protein that belongs to the TPT transporter family and exists as multiple alternatively spliced isoforms. Expressed ubiquitously and functionally induced in hypoxic trophoblast cells, SLC35C2 plays a role in the cellular response to tissue hypoxia and is thought to be involved in the pathogenesis of ovarian cancer. The gene encoding SLC35C2 maps to human chromosome 20, which houses over 600 genes some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
Function:
May play an important role in the cellular response to tissue hypoxia.
Subcellular Location:
Membrane.
Tissue Specificity:
Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.
Similarity:
Belongs to the TPT transporter family. SLC35C subfamily.
Database links:
Entrez Gene: 514485 Cow
Entrez Gene: 609863 Dog
Entrez Gene: 100056733 Horse
Entrez Gene: 51006 Human
Entrez Gene: 228875 Mouse
Entrez Gene: 100152375 Pig
Entrez Gene: 100349356 Rabbit
Entrez Gene: 311637 Rat
Entrez Gene: 323482 Zebrafish
SwissProt: Q9NQQ7 Human
SwissProt: Q8VCX2 Mouse
Unigene: 593344 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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