background:
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012].
Function:
Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.
Subunit:
Homotrimer or heterotrimer with other ASIC proteins.
Subcellular Location:
.Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti.
Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN4 subfamily.
Database links:
Entrez Gene: 55515 Human
Entrez Gene: 241118 Mouse
Entrez Gene: 63882 Rat
Omim: 606715 Human
SwissProt: Q96FT7 Human
SwissProt: Q7TNS7 Mouse
SwissProt: Q9JHS6 Rat
Unigene: 87469 Human
Unigene: 110790 Mouse
Unigene: 44831 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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