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Rabbit Anti-ACCN2/FITC Conjugated antibody
background:
Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.
Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Subunit:
Homotrimer or heterotrimer with other ASIC proteins. Interacts with STOM and ASIC2. Interacts with PRKCABP.
Subcellular Location:
Cell membrane. Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.
Tissue Specificity:
Expressed in most or all neurons.
Post-translational modifications:
Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.
Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
ACCN2 subfamily.
Database links:
Entrez Gene: 41 Human
Entrez Gene: 11419 Mouse
Entrez Gene: 79123 Rat
Omim: 602866 Human
SwissProt: P78348 Human
SwissProt: Q6NXK8 Mouse
SwissProt: P55926 Rat
Unigene: 274361 Human
Unigene: 88107 Mouse
Unigene: 37385 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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